moflow


moflow

My name is Shareef Dabdoub. I am currently a Research Assistant Professor at The Ohio State University, College of Dentistry specializing in Bioinformatics and data visualization, especially as applied to microbiome research. Currently I am working to understand the causes of oral diseases as related to shifts in the ecology of the oral microbiome.

My most recent publication, Adverse effects of electronic cigarettes on the disease-naive oral microbiome (Science Advances) was the first in-depth investigation of the effects of e-cigarettes on the human oral microbiome. Using whole metagenome sequencing, cytokine analysis, fluorescent and SEM imaging, and machine learning, we show that e-cigarettes create an environment with the potential to lead to disease. Furthermore, we found that it is not just nicotine that causes problems. The liquid used in e-cigarettes is mostly a mixture of propylene glycol (PG) and vegetable glycerin (VG). We found just those together, without nicotine or flavors, causes significant changes in the growth patterns of oral bacteria. Ultimately the evidence in this research brings into question industry safety claims and whether e-cigarettes should be used for smoking cessation. I am the author of PhyloToAST, aimed at analysis and visualization of microbiome data. Also kraken-biom (and the related clark-biom).

General Interests:
I am a Computational Biologist/Bioinformaticist with a background in both Computer Science and Biology. My main research interests involve scientific data visualization, microbial ecology, open source software, machine learning, image analysis and genetics.

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